Journal article
Validation of a digit symbol substitution test for use in supervised and unsupervised assessment in mild Alzheimer’s disease
M Williamson, P Maruff, A Schembri, H Cummins, L Bird, E Rosenich, YY Lim
Journal of Clinical and Experimental Neuropsychology | Published : 2022
Abstract
Introduction: The Digit-Symbol-Substitution Test (DSST) is used widely in neuropsychological investigations of Alzheimer’s Disease (AD). A computerized version of this paradigm, the DSST-Meds, utilizes medicine-date pairings and has been developed for administration in both supervised and unsupervised environments. This study determined the utility and validity of the DSST-Meds for measuring cognitive dysfunction in early AD. Method: Performance on the DSST-Meds was compared to performance on the WAIS Coding test, and a computerized digit symbol coding test (DSST-Symbols). The first study compared supervised performance on the three DSSTs versions in cognitively unimpaired (CU) adults (n = 1..
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Awarded by Alzheimer's Association
Funding Acknowledgements
Funding for the AIBL study was provided in part by the study partners [Australian Commonwealth Scientific Industrial and Research Organization (CSIRO), Edith Cowan University (ECU), Florey Institute, University of Melbourne), Dementia Australia (DA), Austin Health, CogState Ltd., Sarich Institute]. The study also received support from the National Health and Medical Research Council GNT1162645, GNT2009550, GNT1171816 (NHMRC). YY Lim is supported by an NHMRC Career Development Fellowship (GNT1162645) and an NHMRC Emerging Leadership Grant (GNT2009550).We thank all AIBL and BetterBrains participants for their commitment and dedication to helping advance research into the early detection and causation of Alzheimer's disease.